Reading Horowitz's "...Emerging Viruses" is an eye opening experience. He shows the mutation of virus and gives locations of German labs that work on such in Zaire, Africa. Her we see how Virology's gone amuck with introduction into humans intentionally.
EXCERPT BEGINS
http://www.nalusda.gov/ttic/tektran/data/000009/05/0000090536.html
INDUCTION OF JAPANESE ENCEPHALITIS VIRUS-SPECIFIC CYTOTOXIC T
LYMPHOCYTES IN HUMAN BY POXVIRUS-BASED JE VACCINE CANDIDATES
Author(s):
KONISHI EIJI
KURANE ICHIRO
MASON PETER W
SHOPE ROBERT E
KANESA-THASAN NIRANJAN
SMUCNY JOHN J
HOKE CHARLES H
ENNIS FRANCIS A
Interpretive Summary:
Japanese encephalitis (JE) is a mosquito-borne viral disease that infects pigs, horses, and humans in many areas of the Far East and Southeast Asia. Japanese encephalitis virus (JEV) infection of pregnant swine can cause abortion, and many of the successfully delivered offspring suffer irreversible brain damage. JEV infections of humans or horses can result in a severe brain infection known as encephalitis. Current vaccines for JE consist of chemically inactivated viruses prepared from JEV-infected suckling mice. Preparation of these vaccines is dangerous and time consuming. In an attempt to develop new vaccines, we have been engineered and tested genetically engineered poxviruses that encode a some of the protein immunogens of JEV. These poxviruses have been shown to be safe and effective vaccines for JE in mice and swine. The current work describes the further characterization of these recombinant poxviruses. Specifically, we have demonstrated that these viruses can be safely administered to human volunteers, and that the vaccinees produced immune responses, including antibodies and cytotoxic (killer) T- lymphocytes (cells) that are capable of destroying JEV-infected cells. However, immune responses were reduced in vaccinees who had a history of vaccination against smallpox.
Keywords:
virology aphthovirus disease recombinant dna receptor
Contact:
P O BOX 848
GREENPORT LI
ORIENT POINT
NY 11944
FAX: (516)323-2507
Email: PeterMas@ASRR.ARSUSDA.GOV
Approved Date: 1999-01-14
TEKTRAN
United States Department of Agriculture
Agricultural Research Service
Updated: 1999-01-16
Patricia A. Doyle, PhD
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es
Zhan le Devlesa tai sastimasa
Go with God and in Good Health
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